By Leon P. Bignold

In 1890, quite a few years after the invention of the chromosomes, David Paul Hansemann, a pathologist-in-training with the recognized Rudolph Virchow in Berlin, produced a idea of the pathogenesis of melanoma concerning the most important present notion: that the 1st switch which happens in melanoma is an alteration of the hereditary fabric of a typical telephone on the web site the place the cancerous technique begins.

In the method of linking melanoma to chromosomal fabric, Hansemann coined the phrases "anaplasia" and "dedifferentiation". those phrases have remained the root of descriptive phrases about the microscopical appearances of tumours ever due to the fact. however, regardless of the recognition of his terminology, Hansemann's rules have been attacked vigorously by way of just about all proponents of rival theories of the character of melanoma. in part as a result of those disputes in the course of his life-time, and partially as a result of different elements, curiosity in von Hansemann's principles reduced through the 20th century and his works are infrequently pointed out this day.

This publication offers translations of the entire correct German texts, and analyses the historical past and context of Hansemann's theories in addition to the explanations why he used to be virtually thoroughly forgotten. It exhibits that a few of Hansemann’s rules should still be appropriate to melanoma learn this present day, and that he merits to be remembered with regards to melanoma as Vordenker unter den führenden Denkern seiner Zeit - the main of the major thinkers of his time.

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In 1890, quite a few years after the invention of the chromosomes, David Paul Hansemann, a pathologist-in-training with the well-known Rudolph Virchow in Berlin, produced a concept of the pathogenesis of melanoma concerning the foremost present inspiration: that the 1st switch which happens in melanoma is an alteration of the hereditary fabric of a typical telephone on the website the place the cancerous method starts.

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Additional resources for David Paul von Hansemann: Contributions to Oncology: Context, Comments and Translations

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However,the“Cellular Pathology” had the characteristics of a “philosophy of pathology”, as discussed in the next section. The general characteristics of Virchow’s thinking included: (i) Persistent influence of the Ancient Greeks, which was evident in his acceptance of “life forces” as a biological mechanism (see above). (ii) Inclination to overarching concepts. ”. (iii) Romantic notions of the role of medicine in society, and the dramatic moments which “turn” medical history. These are to be found especially in his articles in his journal “Medical Reform” (1848-9) (Ackerknecht, 1957, Rather, 1962, 1971; Virchow, 1907).

However,T. H. Huxley20 (1825–1895), widely referred to as “Darwin’s bulldog”, remained committed to evolution to the end of his life, although he was concerned with what he saw as the dubious moral and ethical ideas which some authors were deriving from Darwin’s theory. In Germany generally, Darwin’s theory did not cause such great controversy as it did in England, perhaps because the Lutheran Church was less interested in biological matters, and further, perhaps because the tolerant attitude to diversity of religious beliefs in the era of Fredrick the Great (1712–1786) may not have faded.

A later contributor was Jacob Böhme (1575–1624), who was foremost among the Silesian Pietist Mystics after the Reformation. 6 Christian Thomasius (1655–1724)was a lawyer and a professor of philosophy (in Leipzig and after being proscribed there, as a Foundation Professor at the University of Halle). Initially he sought to divorce natural law from theology. This was similar to Descartes’ purpose (see note 2 above). Thomasius was opposed to prejudice, belief in superstitions, religious persecution, witch-hunts and the use of torture.

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