By Frederick J. de Serres Ph.D. (auth.), Frederick J. De Serres, Michael D. Shelby (eds.)

Frederick J. de Serres, Ph. D. place of work of the affiliate Director for Genetics nationwide Institute of Environmental healthiness Sciences learn Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis used to be orga­ nized to start the method of challenge identity and backbone touching on our must overview the information on attempt chemical compounds coming up from assays for mutagenic job on laboratory organisms. some time past, information on chemical mutagens has been generated and released within the medical literature on a kind of random foundation. person chemical compounds get pleasure from a short interval of "popularity" that ends up in a burst of guides within the related or occasionally similar assay structures. The incompleteness of the knowledge base, in lots of of those instances, makes comparative mutagenesis tricky or most unlikely. In our makes an attempt to match the genetic results of a given chemical over quite a lot of assay structures, we're frequently drawn to making quantitative in addition to qualitative compari­ sons. To restate the 1st comparability: is the chemical less than ques­ tion a vulnerable, average or powerful mutagen over quite a lot of assay systems--or then again, does the extent of reaction fluctuate markedly? To make the second one comparability, what's wanted is info at the spectrum of genetic changes produced in addition to no matter if this spectrum is constant over a variety of organisms.

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Comparisons between potencies of different chemicals must be undertaken with caution (1,3). c8_9 : (+) 8-9 required for activity; (-) 8-9 not required for activity; (+) tested in the presence and absence of 8-9 (for nonmutagenic compounds), or that compound is slightly more active in the presence of S-9 (vinyl chloride). d The Salmonella tester strain for which dose response data are reported. For nonmutagenic compounds, indicates strains on which the compound was tested. e , 'd assay. Llqul fDesiccator experiment.

It would be of interest to confirm the mutagenicity of theS;-;etabolites in Salmonella on strains TA1535 and TAlOO. Diethylnitrosamine Diethylnitrosamine (DEN) was first shown to be a mutagen in 37 Salmonella/MICROSOME MUTAGENICITY TEST Salmonella on strain hisG46 by MaIling (23), and subsequently Bartsch, Malaveille, and Montesano (24) showed that it was mutagenic on strain TA1530 (Table 4). Activity required preincubating the bacteria and DEN in the presence of a liver microsomal fraction. The dose-response curve given here (Fig.

S. Res. 31: 970-973 (1971). Proe. 12th Inter. Congr. Genet. 3: 225-245 Cancer Res. 32: 2369-2374 (1972). Cancer CHAPTER 4 MUTAGENICITY OF SELECTED CHEMICALS IN THE SALMONELLA/MICROSOME MUTAGENICITY TEST Lynne Haroun and Bruce N. Ames Department of Biochemistry, University of California at Berkeley, Berkeley, California 94720 The Salmonella/microsome mutagenicity test provides a simple, economical method for detecting chemical mutagens. Compounds are tested on Petri plates with several specially constructed mutants of Salmonella typhimurium which have been selected for their sensitivity and specificity in being reverted from a histidine requirement back to prototropy.

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