By Leon P. Bignold
In 1890, quite a few years after the invention of the chromosomes, David Paul Hansemann, a pathologist-in-training with the recognized Rudolph Virchow in Berlin, produced a idea of the pathogenesis of melanoma concerning the most important present notion: that the 1st switch which happens in melanoma is an alteration of the hereditary fabric of a typical telephone on the web site the place the cancerous technique begins.
In the method of linking melanoma to chromosomal fabric, Hansemann coined the phrases "anaplasia" and "dedifferentiation". those phrases have remained the root of descriptive phrases about the microscopical appearances of tumours ever due to the fact. however, regardless of the recognition of his terminology, Hansemann's rules have been attacked vigorously by way of just about all proponents of rival theories of the character of melanoma. in part as a result of those disputes in the course of his life-time, and partially as a result of different elements, curiosity in von Hansemann's principles reduced through the 20th century and his works are infrequently pointed out this day.
This publication offers translations of the entire correct German texts, and analyses the historical past and context of Hansemann's theories in addition to the explanations why he used to be virtually thoroughly forgotten. It exhibits that a few of Hansemann’s rules should still be appropriate to melanoma learn this present day, and that he merits to be remembered with regards to melanoma as Vordenker unter den führenden Denkern seiner Zeit - the main of the major thinkers of his time.